Invariant Vα7.2-Jα33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells
Identifieur interne : 004229 ( Main/Exploration ); précédent : 004228; suivant : 004230Invariant Vα7.2-Jα33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells
Auteurs : Agnes Peterfalvi ; Eva Gomori ; Tamas Magyarlaki ; Jozsef Pal ; Miklos Banati ; Andras Javorhazy ; Julia Szekeres-Bartho [Hongrie] ; Laszlo Szereday [Hongrie] ; Zsolt Illes [Hongrie]Source :
- International Immunology [ 0953-8178 ] ; 2008-10-16.
Abstract
The anti-tumor response of human invariant NKT (NKT) cells is well established. A novel T cell subset, mucosal-associated invariant T (MAIT) cells, possesses similar regulatory properties to NKT cells in autoimmune models and disease. Here, we examined the clonality of four T cell subsets expressing invariant αTCR, including Vα7.2-Jα33 of MAIT cells, in 19 kidney and brain tumors. The MAIT clonotype was identified and co-expressed with NKT clonotype in half of the tumors. In contrast, two other invariant T cell clonotypes (Vα4 and Vα19) were not present in tumors. Such tumors also expressed Vβ2 and Vβ13, the restricted TCRβ chain of MAIT cells and the antigen-presenting molecule MR1. A high percentage of infiltrating T cells was CD8+ and expressed HLA-DR suggesting activation. Although the MAIT αTCR was identified in both peripheral CD56+ and CD56− subsets, infiltrating lymphocytes were CD56 negative. The clonal presence of MAIT cells in tumors correlated with the expression of pro-inflammatory cytokines but no IL-4, IL-5 and IL-10, suggesting that a pro-inflammatory subset of human MAIT cells may exist. Our data imply that a CD56− subset of MAIT cells may participate in tumor immune responses similarly to NKT cells.
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DOI: 10.1093/intimm/dxn111
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E" first="Eva" last="Gomori">Eva Gomori</name><affiliation><wicri:noCountry code="no comma">Department of Pathology</wicri:noCountry></affiliation></author><author><name sortKey="Magyarlaki, Tamas" sort="Magyarlaki, Tamas" uniqKey="Magyarlaki T" first="Tamas" last="Magyarlaki">Tamas Magyarlaki</name><affiliation><wicri:noCountry code="no comma">Department of Laboratory Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Pal, Jozsef" sort="Pal, Jozsef" uniqKey="Pal J" first="Jozsef" last="Pal">Jozsef Pal</name><affiliation><wicri:noCountry code="no comma">Department of Neurosurgery</wicri:noCountry></affiliation></author><author><name sortKey="Banati, Miklos" sort="Banati, Miklos" uniqKey="Banati M" first="Miklos" last="Banati">Miklos Banati</name><affiliation><wicri:noCountry code="no comma">Department of Neurology</wicri:noCountry></affiliation></author><author><name sortKey="Javorhazy, Andras" sort="Javorhazy, Andras" uniqKey="Javorhazy A" first="Andras" 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sort="Illes, Zsolt" uniqKey="Illes Z" first="Zsolt" last="Illes">Zsolt Illes</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hongrie</country></affiliation></author></analytic><monogr></monogr><series><title level="j">International Immunology</title><idno type="ISSN">0953-8178</idno><idno type="eISSN">1460-2377</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-10-16">2008-10-16</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1517">1517</biblScope><biblScope unit="page" to="1525">1525</biblScope></imprint><idno type="ISSN">0953-8178</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-8178</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The anti-tumor response of human invariant NKT (NKT) cells is well established. A novel T cell subset, mucosal-associated invariant T (MAIT) cells, possesses similar regulatory properties to NKT cells in autoimmune models and disease. Here, we examined the clonality of four T cell subsets expressing invariant αTCR, including Vα7.2-Jα33 of MAIT cells, in 19 kidney and brain tumors. The MAIT clonotype was identified and co-expressed with NKT clonotype in half of the tumors. In contrast, two other invariant T cell clonotypes (Vα4 and Vα19) were not present in tumors. Such tumors also expressed Vβ2 and Vβ13, the restricted TCRβ chain of MAIT cells and the antigen-presenting molecule MR1. A high percentage of infiltrating T cells was CD8+ and expressed HLA-DR suggesting activation. Although the MAIT αTCR was identified in both peripheral CD56+ and CD56− subsets, infiltrating lymphocytes were CD56 negative. The clonal presence of MAIT cells in tumors correlated with the expression of pro-inflammatory cytokines but no IL-4, IL-5 and IL-10, suggesting that a pro-inflammatory subset of human MAIT cells may exist. Our data imply that a CD56− subset of MAIT cells may participate in tumor immune responses similarly to NKT cells.</div></front></TEI><affiliations><list><country><li>Hongrie</li></country></list><tree><noCountry><name sortKey="Banati, Miklos" sort="Banati, Miklos" uniqKey="Banati M" first="Miklos" last="Banati">Miklos Banati</name><name sortKey="Gomori, Eva" sort="Gomori, Eva" uniqKey="Gomori E" first="Eva" last="Gomori">Eva Gomori</name><name sortKey="Javorhazy, Andras" sort="Javorhazy, Andras" uniqKey="Javorhazy A" first="Andras" last="Javorhazy">Andras Javorhazy</name><name sortKey="Magyarlaki, Tamas" sort="Magyarlaki, Tamas" uniqKey="Magyarlaki T" first="Tamas" last="Magyarlaki">Tamas Magyarlaki</name><name sortKey="Pal, Jozsef" sort="Pal, Jozsef" uniqKey="Pal J" first="Jozsef" last="Pal">Jozsef Pal</name><name sortKey="Peterfalvi, Agnes" sort="Peterfalvi, Agnes" uniqKey="Peterfalvi A" first="Agnes" last="Peterfalvi">Agnes Peterfalvi</name></noCountry><country name="Hongrie"><noRegion><name sortKey="Szekeres Bartho, Julia" sort="Szekeres Bartho, Julia" uniqKey="Szekeres Bartho J" first="Julia" last="Szekeres-Bartho">Julia Szekeres-Bartho</name></noRegion><name sortKey="Illes, Zsolt" sort="Illes, Zsolt" uniqKey="Illes Z" first="Zsolt" last="Illes">Zsolt Illes</name><name sortKey="Szereday, Laszlo" sort="Szereday, Laszlo" uniqKey="Szereday L" first="Laszlo" last="Szereday">Laszlo Szereday</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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